Anyone else experienced bugs with the looting system?

Just went to open a chest from my loot with a key I had forged, however when I clicked to open nothing happened. I clicked in and out of the loot section to come back and find my chest and key gone with no loot left behind at all. This is not the first bug I have experienced with the looting system and I was wondering if anyone else has experienced any other bugs? ( {{champion:121}} ) if so, what happened?
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